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Vanilla 220.127.116.11 is available for download. It is strongly recommended for all sites running Vanilla 2.0 to upgrade immediately. It contains 3 security patches and ditches the troublesome "Remove" option on the plugins page.
If you are currently running 18.104.22.168, no other steps are required than copying the new files over your old ones.
Feeling a little selective? These are the exact files that changed:
Please note that 2.1 is currently in release candidate stage, so it is imminent for stable release. We will continue to support 2.0 with security patches thru the end of 2014.